Science et thérapie du cancer

Occult Prostate Cancer: Condylar Mandibular Metastasis Like Unique Manifestation. Rare case report, First Described in Italian Literature

Abstract

MG Cristofaro, Giudice A, Colangeli W, Giofrè E, Riccelli U and M Giudice

Prostate cancer is the most frequently diagnosed cancer in men and the second leading cause of cancer death among men in the United States. The most common site of prostate cancer metastasis is the bone, with skeletal metastases identified at autopsy in up to 90% of patients dying from prostate cancer. The route of metastasis to bone is thought the prostatic venous plexus draining with the vertebral veins. In this report jaw bones metastases occur before the patient has been diagnosed a primary tumour; in a smaller rate their diagnoses coincides with the diagnosis of the primary tumour. Data reported in literature a low incidence of jaw bones metastases; they are even less recurrent in mandibular condyles owing to their low red bone marrow (hematopoietic active) content in adulthood. Just in a few exceptional cases, like this case, bone metastases is the first clinical evidence of an occult or initial cancer, a site occurs above all in prostate, bladder and lung cancer. Our case are exceptional because the mandibular condyle metastasis was the first clinical sign of an occult primary prostate carcinoma, whose early diagnosis made the treatment of both (primary tumour and sigle metastasis) more effective.