Journal d'histologie moléculaire et de physiologie médicale

Neoantigens: The Cutting-Edge Precision Cancer Vaccine

Abstract

Huang Hong

Cancer has long been a formidable adversary in the realm of medical science. It's a disease that can originate from various tissues and affect virtually any part of the body, making it a complex and elusive target. While cancer treatment has evolved significantly over the years, the development of effective and precise therapeutic strategies has remained a major challenge. However, recent advancements in the field of immunotherapy have given rise to a promising approach known as neoantigen-based cancer vaccines. This cutting-edge technology holds the potential to revolutionize cancer treatment, offering personalized therapies that target the specific mutations in a patient's cancer cells. In this article, we will explore the concept of neoantigens, their significance in the realm of cancer immunotherapy, and the development of precision cancer vaccines. Neoantigens, a term derived from "new antigens," refer to a class of antigens that are unique to an individual's tumor cells. These antigens arise from mutations in a patient's DNA, either due to genetic predisposition or environmental factors, such as exposure to carcinogens. Neoantigens play a crucial role in the immune system's ability to distinguish between healthy cells and cancerous ones.