Chimie médicale

Metal Complexes and Organotin(IV) Compounds of Cefixime and their Biological Study

Abstract

Muhammad Danish, Muhammad Asam Raza, Tooba Ilyas, Amina Sharif and Nargis Anjum

Synthetic chemistry is playing revolutionary role in human beings by synthesizing novel compounds by different techniques. The present study was designed to prepare bioactive compoundsand evaluate their antioxidantand enzyme inhibition studies. Metal complexes of cefixime were prepared by reacting metal salts of different transition metals with sodium salt of cefixime. Their characterization was done with melting point and FTIR studies which confirmed the synthesis of metal complexes. It was concluded from results that synthesized compounds showed very weak response against AChE and some extent to BChE. In contrast to esterase family protease was inhibited significantly and T4 exhibited more than 90% inhibition (93.2 ± 0.1%). Antioxidant study was conducted using well known DPPH free radical assay while enzyme inhibition potential was evaluated according to standard protocols. Maximum antiradical activitywas exhibited by T6 (80.84 ± 1.6%) with IC50 45 ± 2 μg/ml while T5 remained almost inactive. Antibacterial studies have been carried out against Escherichia coli and Bacillus subtilis.