Science et thérapie du cancer

Medullary Breast Carcinoma: A Case Report and Review of Literature

Abstract

Santosh T, Atanu Kumar Bal, Manoj Kumar Patro and Anita Choudhury

Medullary breast carcinomas (MBCs) represent <5% of all invasive breast carcinomas and although these tumors show aggressive pathological features they are often associated with a more favourable outcome. It is also said to be particularly common in carriers of BRCA1 mutations. They are almost invariably negative for hormone receptors as well as Her-2/neu (‘triple negative’ phenotype). The prognosis for medullary carcinoma is better than for the ordinary invasive ductal carcinoma, a fact already apparent in the early reports on this tumor. We report a similar case in a 56 year old female with cytological, histological and immunohistochemical analysis of MBC.