Journal de la colonne vertébrale

Male Mouse Serum Lipidomic Signatures are Changed by Boldine Following Acute Spinal Cord Transection

Abstract

Zeerde Zoesr

Acute spinal cord transection is a devastating injury that can lead to profound functional impairment and altered physiological responses throughout the body. Recent studies have shown that boldine, a natural alkaloid found in the leaves and bark of boldo tree (Peumus boldus), exhibits neuroprotective properties. However, the systemic effects of boldine on lipidomic signatures in the context of acute spinal cord transection remain poorly understood. This article explores the potential impact of boldine on male mouse serum lipidomic profiles following acute spinal cord transection, shedding light on its therapeutic potential beyond its direct neuroprotective effects.