Science et thérapie du cancer

Lineage Switch from Acute Lymphoid Leukemia to Acute Myeloid Leukemia

Abstract

Maryam Pourabdollah, Babita Kajal and Hong Chang

Lineage switch acute leukemia is a rare condition mostly reported in pediatrics. Despite new advances in the treatment of acute leukemia, switching between lymphoid and myeloid lineages at relapse could worsen outcome of the disease. Awareness of this phenomenon might be beneficial in terms of early detection and applying more aggressive or more specific therapy specially in the context of some genetic alterations.