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Journal des essais cliniques sur le cancer

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Interstitial Pneumonitis in a Patient with Occult Sarcoidosis Treated with Pembrolizumab for Advanced Melanoma

Abstract

Irene J Tan*, J Bui and MA Khattak

We report on a case of a 68-year-old man with metastatic melanoma presenting with interstitial pneumonitis following initiation of pembrolizumab, in the setting of occult sarcoidosis. There have been no previous reports on pembrolizumab inducing a flare of sarcoidosis. This patient was managed with high dose steroids with improvement in his respiratory symptoms. The use of immunotherapy in the management of various solid tumours is increasing and clinicians from different specialities need to be aware of the potential toxicities associated with this class of drugs that can affect multiple organs.

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