Chimie médicale

In Silco Molecular Modeling of Chalcone Based Aryloxyethylamines as Antihyperglycemic Agents

Abstract

Poonam Shukla, Ram Pratap, Shalini Singh, Neha Rahuja, Ashok K Prasad and Arvind Kumar Shrivastava

Despite enormous efforts have been made in the search for new drugs, diabetes mellitus (DM) still remains the cause of mortality worldwide. A series of chalcone based aryloxyethylamines were synthesized and evaluated for their anti-hyperglycemic activity in SLM and STZ rat models. The majority of the compounds exhibited temperate to good activity ranging from 18.0% to 39.8% in SLM and 14.6% to 31.5% in STZ models, respectively. The most potent compound 31 exhibited glucose lowering of 27.0% in SLM and 31.5% in STZ models. A definite structure–activity relationship was observed while varying the nature and position of the different amines in ring-A of chalcone.