Troubles neurologiques

Implication of the JAK-STAT Pathway in Gliomagenesis: A Target for Therapy?

Abstract

Elias A El Habr, Christos Adamopoulos, Georgia Levidou, Vassilis Samaras3, Athanasios Zisakis, Penelope Korkolopoulou and Christina Piperi

Gliomas, being the most prevalent and aggressive malignancy of the central nervous system, are associated with poor prognosis and very low survival rates. Failure of malignant glioma cells to respond to conventional cancer therapies is attributed to their infiltrating and immunosuppressive phenotype along with increased molecular heterogeneity. Current evidence implicates aberrant JAK-STAT signaling and expression of STAT inhibitors in the molecular pathogenesis of gliomas. This review provides a critical account of recent evidence regarding JAK-STAT signaling components in gliomagenesis, highlighting the potential therapeutic benefits and perspectives of targeting this pathway.