Joarder MHH, Islam MU, Ahamed K, Yameen MB, Sharmin R, Alam AHMK and Islam A
Mikania scandens (M. scandens) has been proposed to have several medicinal values for different ailments. This study evaluated the ethanolic extract of M. scandens leaves for its phyto-constituents, hypoglycemic, hypolipidemic and hepatoprotective effects in Alloxan Induced Diabetic Mice (AIDM). Phytochemical analysis was conducted using standard procedures while the anti-diabetic and hepatoprotective effects were determined using AIDM. The results of the phytochemical screening indicated the presence of steroids, alkaloids, phytosterol, flavonoids, phenolic compound, fatty acids and glycosides. The percentage reduction of blood glucose level was 33.18%, 33.19%, 54.77%, 75.29% & 80.93% in 4, 8, 12, 16 and 20 hours respectively. In case of HDL lowering activity, it showed similar reduction (33.83%) level of HDL compared metformin (32.29%), while 85.08% reduction was observed in case of LDL. The extract also significantly decreased (74.08%, p<0.001) the TG level while it lessened 69.7% of total cholesterol compared to metformin (76.70%). In addition to that comparative hepatoprotective activity revealed the significant reduction in sGPT (83.66%) and sGOT (76.14%) level which almost similar to metformin activity. Taken together, this study revealed that ethanolic extract of M. scandens leaves contain bioactive constituents with antidiabetic potentials, which goes to support its acclaimed traditional medical use of the plant in the management of diabetes.
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