Journal d'histologie moléculaire et de physiologie médicale

Histological and Immunocytochemical Analysis of Acne

Abstract

Janaki Madhuri

Acne is a prevalent dermatological condition that affects millions of individuals worldwide, leading to both physical and psychological distress. This study presents a comprehensive histological and immunocytochemical analysis of acne lesions, aiming to enhance our understanding of the underlying pathophysiological mechanisms. Skin biopsies were obtained from acne-affected areas of patients and histological examinations revealed distinct features, including sebaceous gland hypertrophy, follicular hyperkeratosis and inflammatory infiltrates. Immunocytochemical staining was performed to investigate key molecules involved in the inflammatory response, such as cytokines, chemokines and immune cell markers. Our findings shed light on the intricate cellular and molecular interactions within acne lesions, paving the way for potential targeted therapeutic interventions. This research contributes valuable insights into the histopathology of acne, offering a foundation for future studies and innovative treatment strategies.