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Heterocycles for Alzheimer Disease: 4- and 5-Substituted Benzothiophenes as Starting Scaffold in the Construction of Potential New Inhibitors of BACE 1

Abstract

Maria Funicello, Iole Cerminara and Lucia Chiummiento

4- and 5-substituted benzothiophenes were synthesized as starting scaffold in the construction of benzothieno[b] pyridines. Such structures were designed as potential new inhibitors of BACE 1. Preliminary promising biological data were reported. These molecules represent a starting point for improved chemicals in Alzheimer’s disease treatment. Obtained preliminary results encourage research advance and further developments.

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