Chimie médicale

Facile Synthesis of 1-(substituted phenyl)-2-phenyl-4-(substituted benzylidine)-imidazole-5-ones and Antifungal Activity Studies against Phytopathogens

Abstract

Christopher Voosala, Nagendra Sastry Yarla, Manga Rao Nakka and Siddaiah Vidavaluri

A series of five new 1-(substituted phenyl)-2-phenyl-4-(substituted benzylidine)-imidazole-5-one derivatives (or) 5(4 H )-imidazolones have been synthesised adopting 3 o A Zeolite as catalyst. These compounds were assayed for their antifungal activityon three different selected phytopathogens which disparately affects the Jowar crop (Sorghum Vulgare) of Poaceae family. Among the tested molecules, compound 18 exhibited potent inhibitory activity when compared to the Bavistine (Positive control).