Journal de pathogenèse microbienne

Exploring the Gut Microbiome Changes Associated with Anorexia Nervosa

Abstract

Stephan Ahearn

Anorexia Nervosa (AN) is a severe psychiatric disorder characterized by restricted food intake, distorted body image, and intense fear of gaining weight. While the exact etiology of AN remains multifactorial and incompletely understood, emerging evidence suggests a potential role of gut microbiome alterations in disease pathogenesis. In this review, we explore the gut microbiome changes associated with AN, focusing on microbial composition, diversity, and functional profiles. Through comprehensive analysis of available literature, we discuss the potential mechanisms underlying gut dysbiosis in AN, including altered nutrient absorption, intestinal permeability, and immune function. Furthermore, we examine the implications of gut microbiome alterations in AN prognosis and treatment outcomes, highlighting the therapeutic potential of microbiota-targeted interventions in this complex psychiatric disorder.