Immunochimie et immunopathologie

Exploring Co-Inhibitory Receptor (Co-IR) Expression on T Cells and Soluble Proteins in Rheumatoid Arthritis: A Comprehensive Analysis

Abstract

Saruli Vantey*

Rheumatoid Arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and joint destruction. T cells play a pivotal role in the pathogenesis of RA, with Co-Inhibitory Receptors (Co-IRs) modulating T cell responses. This review examines the comprehensive expression profile of Co-IRs on T cells and soluble proteins in RA, elucidating their roles in disease progression and therapeutic targeting. Through a systematic analysis of current literature, this review highlights the intricate interplay between Co-IRs and T cell function in RA pathogenesis, shedding light on potential avenues for therapeutic intervention. Furthermore, this review explores the dynamic interactions between Co-IRs and soluble proteins within the complex immunological milieu of RA. By examining the expression patterns and functional implications of Co-IRs on T cells, as well as their modulation by soluble factors, a deeper understanding of the immunopathogenesis of RA emerges. Insights gleaned from this analysis hold promise for the development of novel immunotherapeutic strategies aimed at restoring immune balance and ameliorating disease activity in RA patients.