Toxicologie environnementale et analytique

Evaluation of Iron Supplementation Effects on Various Serum Minerals in Pregnant Anaemic Patients of Sargodha Region

Abstract

Zahoo Ul Hassan Dogar, Iram Latif, Ain Nus Saba, Sshamsa Kanwal, Khalil Ul Rahman, Zafar Iqbal Khan and Kafeel Ahmad

Pregnant anaemic patients of Sargodha region were asked to take oral iron supplementation (150 mg per day) in the form of available medicines up to the period of two months. Blood samples were collected before the initiation of treatment and secondly after the two months of treatment. Evaluation of serum minerals shows that, iron level increases from 65 μg/dl-75 μg/dl in Group-1 and 62 μg/dl-78 μg/dl in Group-2 before and after supplementation respectively this increase is statistically significant (p=0.000). Results shows that iron supplementations have no effect on serum calcium. So values of serum calcium remain same after two months in both groups. Change in P values are statistically insignificant (P>0.05). The mean values of serum calcium remains same in Group-1 is 8.9-9.1 mg/dl (p=0.07), SD=0.66-0.7 and in Group-2 it is 9.0-9.1 mg/dl (p=0.83), SD=0.6-0.7 before and after supplementation respectively and values of serum copper decreases in both groups. Change in P values are statistically insignificant (P>0.05). The mean values of serum Cu in Group-1 is 108-107 μg/dl (p=0.35), SD=28.3-28.0 and in Group-2 it is 110-109 μg/dl (p=0.13), SD=24.4-23.0 before and after supplementation respectively. Serum zinc values significantlydecrease (p=0.00) from 68 μg/dl - 66 μg/dl and 68 μg/dl - 67 μg/dl in Group-1 and Group-2 respectively. It may be dueto positive effect on serum iron level and negative effect on serum zinc status. Serum calcium and copper remainsunaffected from iron supplementation. The variations were almost similar in both age groups (1 & 2) means effects of iron supplementations are similar irrespective of the age of pregnant anaemic patients, the only noticeable change was that variations are comparatively fast in Group-1 as compare to Group-2 it may because of greater absorption of nutrients in young ones than that of aged subjects.