Journal mondial de technologie et d'optimisation

Epitope-Based Vaccine Design against the Outer Membrane Glycoprotein of HCMV

Abstract

Saruar Alam, Mohammad Sayem, Md. Ratul Rahman, Zinat Sharmin, Mahmud Arif Pave and Md. Faruk Hossain

Human cytomegalovirus is also known as (HCMV), a human beta-herpesvirus 5 which affects over 80% adults worldwide. HCMV infection is considered one of the most leading causes of morbidity and mortality during congenital infection. It can be lethal for the immunosuppressed, such as HIV-infected individuals and patients having their organ transplanted. Considering the clinical importance of HCMV, in this study we aim to design epitope based peptides to develop a vaccine against HCMV by targeting the envelope glycoprotein B of HCMV. We predicted total 22 epitopes and their variability were analysed. The analysis of population coverage reveals a high percentage of the coverage for the America and Europe with an overall 69.77% population coverage for the world. Finally, we predicted the 3D structure of epitope YAYIYTTYL and its binding profile with the human leukocyte antigen serotype (HLA-A*02:01 and HLA-A*02:03) were analyzed using Auto Dock Vina. Our study will facilitate the epitope-based vaccine designing of HCMV and could have a far-reaching benefit on the drug development for HCMV associated diseases.