Chimie médicale

In Vitro Antibacterial Activity and Phytochemical Analysis of Zingiber officinale L. Rhizome Extracts

Abstract

Suleiman AG, Hamisu M, Adamu MD, Rabiu S, Abdulrazak MH, Mujaheed A, Usman AH and Marwan I

The aim of this research was to determine antibacterial activity and phyto-chemical screening of ethanolic extracts of Zingiber officinale. Fresh rhizomes of Zingiber officinale (Ginger) were collected from Kachia Local Government Area, Kaduna (Kaduna south) state, Nigeria. The antibacterial activity was determined using agar well diffusion method whereas phytochemical screening was carried out to determine the phytochemical composition of the ginger rhizomes. The result of the Phytochemical screening revealed absence of alkaloids and saponins in all the extracts but showed presence of flavonoids, tannins and steroids. The result for the bioassay presented variation in the biological activity of the extracts. All the extracts exhibited antibacterial activity against all the tested bacteria with zones of inhibition diameter ranging from 7.31-18.67 mm. The highest zone was observed in chloroform extracts on Staphylococcus epidermidis at 100 mg/ml while the least zone of inhibition was observed in n-hexane extracts on Pseudomonas aeruginosa at 25 mg/ml. However, both Klebsiella pneumoniae and Pseudomonas aeruginosa were resistant to n-hexane extracts at 25 mg/ml.