Maladies infectieuses cliniques : accès libre

Elevation in International Normalized Ratio due to Administration of Cefoperazone in Valvular Patients on Warfarin Therapy: Series of Two Case Reports

Abstract

Anam Liaqat*, Muhammad Asad and Arif-Ullah Khan

Warfarin is an oral anticoagulant, which is commonly prescribed in hospital settings in various thrombotic conditions. It is known to have had a broad range of interactions with other medicinal gents widely used during clinical settings, particularly antibiotics, resulting in altered coagulation parameters and bleeding in such patients. In this study, we intend to describe two such cases that developed excessive hypoprothombinemic response due to cefoperazone and improved after substituting cefoperazone with alternative antibiotic. While there is no conclusive proof of warfarin-cefaperazone interactions, it is recommended that healthcare providers explore alternate antibiotic use in warfarin therapy patients and allow careful surveillance of the coagulation profile for all those patients receiving warfarin and antibiotics in combination with warfarin dosage modification.