Chimie médicale

Drug Resistance Analysis of Pasiniazid against Isoniazid-Resistant, Parasal-Resistant, Isoniazid and Parasal-Resitant, and Multidrug-Resistant

Abstract

Liping Yan, Xiaona Shen, Yanli Zhao, Yang Zhou and Heping Xiao

Objective: In view of the high INH resistance, we conducted in vitro drug susceptible test of Isoniazid (INH) and Parasal (PAS) and Pasiniazid (PA) to determine the cross-resistance of the three drugs.

Method: The proportion method on Lo¨wenstein–Jensen (L–J) medium was used to conduct antimycobacterial susceptibility testing of INH and PAS and PA to one hundred and ninety-seven clinical isolates of, including multidrugresistant isolates.

Results: For INH-resistant isolates, PA sensitive rate was as high as 73.6%. The three PAS-resistant isolates were all susceptible to PA. 92% of the isolates resistant to INH and PAS simultaneously were resistant to PA. Most of the isolates susceptible to INH and PAS were also susceptible to PA. More than half of the MDR strains are still sensitive to PA. Almost all of the seventy PA-resistant isolates were also resistant to INH except one isolate. However, 34.3% of the seventy PA-resistant isolates were susceptible to PAS. For MDR isolates in this experiment, PA resistant rate was 46.2%.

Conclusion: PA showed lower susceptibility to the isolate resistant to INH and PAS simultaneously. PAS has strong anti-TB effect. INH is not recommended for the PA-resistant isolates. For single INH resistant cases or MDR cases, we can consider using PA instead of INH.