Journal des biomarqueurs moléculaires et du diagnostic

COVID-19 Spreading Across World Correlates with 677T Allele of the Methylenetetrahydrofolate Reductase (MTHFR) Gene Prevalence

Abstract

Giovanni Ponti, Lorenza Pastorino, Gabriella Oliva, Tomris Ozben, Marco Manfredini, Shaniko Kaleci, Nicoletta Lelli, Raffaele Iannella and Aldo Tomasi

Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR 677T allele and COVID-19 incidence and mortality worldwide. There is a clear trend towards the worldwide prevalence of MTHFR 677T allele and COVID-19 incidence and mortality. The prevalence of MTHFR 677T allele in the Latino population and the incidence and mortality for COVID-19 was higher for this ethnic group than that reported for most other populations globally. Statistical analysis showed a relatively strong correlation between 677T allele and death from coronavirus. Genetic polymorphism of MTHFR C677T may modulate the incidence and severity of COVID-19 pandemic infection.