Immunochimie et immunopathologie

COVID-19 Incidence and Severity Post-vaccination in Kidney Transplant Recipients: Impact of Anti-RBD IgG Antibody Levels

Abstract

Warie Sere*

A cohort of KTRs who received COVID-19 vaccination was monitored for breakthrough infections and anti-RBD IgG antibody levels were measured at regular intervals post-vaccination. Our findings provide insights into the effectiveness of COVID-19 vaccination in KTRs and highlight the importance of monitoring antibody responses for guiding vaccination strategies in immunocompromised individuals. Kidney Transplant Recipients (KTRs) are known to be at increased risk of severe outcomes from COVID-19 due to immunosuppression. With the emergence of COVID-19 vaccines, understanding the incidence and severity of breakthrough infections in KTRs and their association with anti- Receptor-Binding Domain (RBD) IgG antibody levels is critical for optimizing vaccination strategies in this vulnerable population. In this study, we investigated the relationship between anti-RBD IgG antibody levels after COVID-19 vaccination and the incidence and severity of COVID-19 in KTRs.