Journal des biomarqueurs moléculaires et du diagnostic

Co-Expression of XIAP and CIAP1 Play Synergistic Effect on Patient's Prognosis in Head and Neck Cancer

Abstract

Xi-Hu Yang, Liu Liu, Jian-Hui Xu, Yong-Jie Hu, Ping Zhang, Jia-Xuan Qiu

Purpose: To explore the relationship between XIAP and CIAP1 co-expression and the prognosis in HNSCC.

Experimental design: 69 patients were recruited in our study, expression level of XIAP and CIAP1 were examined in all patients, and was correlated with clinical outcomes of the patients.

Results: The patients whose tumors co-express high level of XIAP and CIAP1 presented poorer overall and disease-free survival rates than those whose tumors co-express low level of XIAP and CIAP1 (overall survival P<0.001, disease-free survival P<0.001).

Conclusions: Our results validate that co-expression of XIAP and CIAP1 prompted a worse prognosis.