Journal des rapports de cas cliniques

Axonal Neuropathy as a Rare Side Effect of Sulfasalazine

Abstract

Jamila Essouiri, Amina Mounir, Fatima Ezzahra Abourazzak and Taoufik Harzy

Sulphasalazine, one of the 5-aminosalicylates, is widely used for the treatment of inflammatory bowel diseases and arthritis. Beside its classic adverse effects like blood dyscrasias and hepatic failure, peripheral neuropathy has been reported as a rare adverse drug reaction to sulphasalazine. The mechanism of this neurotoxicity is unknown tell nowaday. We report a case of neurotoxicity that occurs after prolonged use of sulphasalazine. Previously, reported cases of neurotoxicity have not shown improvement of electric signs in nerve conduction study after stopping treatment.