Chimie médicale

Aporphine Alkaloids as Ligands for Serotonin Receptors

Abstract

Nirav Kapadia and Wayne Harding

The aporphine alkaloids are known to have affinities as the dopaminergic, adrenergic and serotonergic receptor system. Hence the aporphine template can be considered as a privileged scaffold for the design of selective monopotent as well as multi-potent Central Nervous System (CNS) ligands. This review attempts to summarize the recent Structure Activity Relationship (SAR) studies of aporphine alkaloids specifically at the serotonin receptor system. Based on the obtained SAR information it can be concluded that aporphines have great potential to be developed as potent serotonergic ligands.