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Journal sur le SIDA et la recherche clinique

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AIDS in Intensive Care Unit Patients: Epidemiology and Outcomes

Abstract

Alessandro Kenji Yassue, Camila Artuzi Oliveira, Claudia Santos Oliveira, Luana Tossolini Goulart, Karina H Oikawa, Amaury C Jorge, Carla Sakuma Oliveira and Péricles AD Duarte

Background: Admission rates to intensive care unit (ICU) remains high in AIDS patients, although data in lowincome countries are scarce. The aim of this study was to evaluate the epidemiology, morbidity and mortality risk factors of HIV/AIDS patients admitted to the ICU of a university hospital in southern Brazil. Methods: Retrospective cohort study with all patients aged >18 years in the ICU from 2004 to 2014 with a diagnosis of HIV/AIDS (previous or newly diagnosed). Results: 1.7% of ICU patients had HIV/AIDS; of these, 67.1% were male, with an average of 40 years. 91.8% of hospitalizations were due to clinical causes, and most patients (83.6%) had no comorbidities. Mean APACHE 25.1, 95.1% required invasive mechanical ventilation (MV), ICU stay 13.9 days, mortality 51.4%. Among AIDS patients, incidence of complications was high: 41.7% acute respiratory distress syndrome (ARDS), 45.8% acute renal failure (ARF), 37.5% pneumonia. Approximately 1/3 had diagnosis during hospitalization and 27.5% were on antiretroviral therapy. Mortality has progressively reduced over the years. Conclusion: The prevalence of HIV/AIDS was 1.7%. This group had a high incidence of complications, which were related to higher mortality. The mortality of this group has decreased in recent years in this population.

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