Chimie médicale

Acoustic and Thermo-Dynamical Investigation of 2-Amino-5-Nitrothiazole- DMSO-Water System at Different Temperatures and Concentration

Abstract

Thakare AR, Dongapure AC and Naik AB

Thiazole is Sulphur and nitrogen containing heterocyclic compounds represents an important family of medicines in the pharmaceutical chemistry having vast biological applications. Due to the presence of hetero atoms in 2-amino-5- nitrothiazole there should be various types of interaction, by undertaking these interactions, ultrasonic study of 2-amino- 5-nitrothiazole in 70:30 (v/v) DMSO-Water mixture at different concentration and temperature is carried out. Speed of sound and denseness of ternary mixture of 2-amino-5-nitrothiazole – 70:30 (v/v) DMSO-water systems has been measured at various temperature (303.15K, 308.15K, 313.15K and 318.15K) and concentrations, to get idea regarding the solute- solvent and solvent – solvent interaction. In present investigation ultrasonic parameters i.e., specific acoustic impedance, relative association intermolecular free length, adiabatic compressibility, and sound speed number has been put forward to say about types of molecular interaction present in the aqueous 70:30 (v/v) DMSO-water solution of various temperatures and concentrations. Strength of molecular interactions was studied with comparisons to change in temperature and change in concentration. The correlation observed represents interpreted in the form of solute-solvent and solvent-solvent interactions at given temperature variation and concentration variations.